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KMID : 0379520050210010039
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한국독성학회지
2005 Volume.21 No. 1 p.39 ~ p.43
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Antibacterial Activity In Vitro and Primary Dermal Irritation Test in Rabbits of Surfactin Produced Bacillus subtilus Complex BC2121
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Hwang Mi-Hyun
Yun Hyo-In
Lim Jong-Hwan
Kim Kil-Soo
Rhee Man-Hee
KIm Nam-Woo
Kim Jong-Choon
Park Seung-Chun
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Abstract
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The present study was carried out to investigate the antibacterial activity against Staphylococcus aureus with antibiotic-resistance in vitro and the skin irritation in rabbits with surfactin produced by Bacillus subtilus Complex BC1212. The antibacterial activities of selected antimicrobial agents (surfactin, amoxacillin, colistin, norfloxacin and streptomycin) were evaluated by using the broth microdilution method. As the results, the minimum inhibitory concentration (MIC) of the surfactin was less than 15.6 ㎍/ml. In the skin irritation test, two out of 4 rabbits showed very slight edema at 24 h after the administration of surfactin, and then recovered at 72 h. The change of body weight was normal during the skin irritation test. The primary irritation index in accordance with the Draize evaluation of topical reaction was calculated to be ’’0.125’’, which meant not irritating. Based on these results, it could be concluded that the test agent, surfactin, was a non-irritant. We could also think that the surfactin may be useful for the treatment of S. aureus infections such as bovine mastitis.
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KEYWORD
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Antibacterial activity, Dermal irritation study, Primary irritation index, Rabbits, Surfactin
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